The Atlantic Coast Conference (ACC) Tournament semifinals will feature a highly anticipated matchup between the No. 2 seed Louisville Cardinals and the No. 3 seed Clemson Tigers on Friday, March 14, 2025. The game is scheduled to tip off at 9:30 p.m. Eastern Time at the Spectrum Center in Charlotte, North Carolina, and will be broadcast on ESPN. So what’s the best bet on the board in tonight’s Clemson vs. Louisville matchup?
Game Matchup & Betting Odds
Clemson Tigers (-1.5) at Louisville Cardinals (+1.5); o/u 140.5
1:00 p.m. ET, Friday, March 14, 2025
Spectrum Center, Charlotte, NC
TV: ESPN
Clemson vs. Louisville Public Betting: Bettors Taking Tigers
Our CBB Public Betting Information page indicates that 59% of public bettors are currently backing Clemson when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
Team Overviews:
Louisville Cardinals: The Cardinals enter the semifinals with a 26-6 overall record, including an 18-2 mark in ACC play. They secured their spot in the semifinals with a narrow 75-73 victory over Stanford in the quarterfinals.
Clemson Tigers: The Tigers boast a 27-5 overall record, also finishing 18-2 in conference play. They advanced to the semifinals after a hard-fought 57-54 win against SMU in the quarterfinals.
Season Series:
Louisville and Clemson did not face each other during the regular season, making this semifinal clash their first meeting of the 2024-2025 campaign.
Key Factors to Watch:
Offensive Efficiency: Both teams have demonstrated the ability to score efficiently. Clemson’s ability to execute their offensive game plan against Louisville’s defense will be crucial.
Defensive Prowess: Louisville’s defense will need to contain Clemson’s key scorers to increase their chances of advancing to the championship game.
Clemson vs. Louisville CBB Prediction:
Considering the evenly matched nature of both teams, this semifinal is expected to be a closely contested battle. While Clemson holds a slight edge according to betting odds and certain predictive models, Louisville’s resilience and recent performances suggest they are more than capable of securing a victory. Fans can anticipate a thrilling game with a potential down-to-the-wire finish.
This is one of the more difficult games to predict on Friday’s college hoops slate. But I’m taking Louisville +2 at Bovada.lv. The Cardinals are red-hot.
Clemson vs. Louisville Hoops Prediction: LOUISVILLE CARDINALS +2