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Lipscomb vs. Iowa State Prediction: Can Cyclones win handily?

Lipscomb vs. Iowa State Lipscomb vs. Iowa State

Fourteen-seed Lipscomb and 3-seed Iowa State both head to Milwaukee to face each other on Friday afternoon in the first round of the NCAA Tournament. The game is at 1:30 PM ET on TNT. Can Iowa State cover the 14.5-point spread as neutral site favorites? Keep reading for our Lipscomb vs. Iowa State prediction.

The Lipscomb Bisons are 25-9 straight up overall this year. They are 16-15-1 ATS this season.

The Iowa State Cyclones are 24-9 straight up overall this year. They are 19-14 ATS this season.

Lipscomb vs. Iowa State Matchup & Betting Odds

795 Lipscomb Bisons (+14.5) vs. 796 Iowa State Cyclones (-14.5); o/u 142.5

1:30 p.m. ET, Friday, March 21, 2025

Fiserv Forum, Milwaukee, WI

TV: TNT

Lipscomb vs. Iowa State Public Betting Information

Our CBB Public Betting Information page indicates that 53% of public bettors are currently backing Lipscomb when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Lipscomb Bisons Game Notes

Bisons guard Joe Anderson was stellar in his team’s 76-65 win over North Alabama on March 9th. In that contest, the Furman transfer put up 23 points, 5 rebounds, 4 assists, 2 steals, and 3 blocks. Anderson shot 6 of 9 from the floor and 4 of 7 from beyond the arc in the victory.

Lipscomb forward Jacob Ognacevic also played well against the Lions two Sundays ago. The senior from Sheboygan, WI recorded 14 points, 9 rebounds, a blocked shot, and a made three-pointer across 40 minutes of game action. Ognacevic leads the team in scoring with 20.1 points per game this season.

Iowa State Cyclones Game Notes

Cyclones guard Keshon Gilbert will miss the team’s first-round game against Lipscomb on Friday due to an undisclosed injury. The 6’4” senior is second on the team in scoring with 13.4 points per game and leads the team in assists with 4.1 assists per contest this season.  

Gilbert’s absence means that senior guard Nate Heise will likely be elevated to the starting lineup. Heise is averaging 4.8 points and 3.2 rebounds per game in 21.2 minutes per contest this season. He’s shooting 49.6% from the field and 37.1% from three-point range on the year.

Lipscomb is 6-4 ATS in their last 10 games overall.

The Bisons are 3-2-1 ATS as an underdog this season.

Iowa State is 4-5 ATS in their last 9 games overall.

The under is 19-14 in Iowa State’s games this season.

The under is 19-13 in Lipscomb’s games this season.

Lipscomb vs. Iowa State CBB Prediction:

These are two teams on seemingly opposite trajectories. Lipscomb is 11-1 straight up since February 1st. The Bisons have 8 double-digit victories in that stretch. By contrast, Iowa State is 7-6 straight up since February 1st. Furthermore, the Cyclones are just 3-4 straight up in their last 7 games. Making matters worse, Iowa State won’t have their second-leading scorer, Keshon Gilbert, for this contest. Gilbert has led the team in scoring 7 times and topped the club in assists 14 times this year. In a game where the Cyclones have to win by 15+ points to cover, I think Gilbert’s absence makes that difficult and proves to be the difference. I’m taking Lipscomb +14.5 points over Iowa State at Bovada.lv.

Lipscomb vs. Iowa State CBB Prediction: LIPSCOMB BISONS +14.5

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