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Notre Dame vs. Duke Prediction: Can Duke overwhelm Notre Dame?

2026 Men's College Basketball 2026 Men's College Basketball

Unranked Notre Dame heads to Durham to face #4 Duke on Saturday afternoon. The game is at 12:00 PM ET on ESPN. Can Duke cover the 19.5-point spread as home favorites? Keep reading for our Notre Dame vs. Duke prediction.

The Notre Dame Fighting Irish are 7-8 straight up in the regular season this year. They are 7-7-1 ATS this season.

The Duke Blue Devils are 13-2 straight up in the regular season this year. They are 10-5 ATS this season.

Notre Dame vs. Duke Matchup & Betting Odds

605 Notre Dame Fighting Irish (+19.5) at 606 Duke Blue Devils (-19.5); o/u 136.5

12:00 p.m. ET, Saturday, January 11, 2025

Cameron Indoor Stadium, Durham, NC

TV: ESPN

Notre Dame vs. Duke Public Betting Information

Our CBB Public Betting Information page indicates that 69% of public bettors are currently backing Notre Dame when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Notre Dame Fighting Irish Game Notes

Fighting Irish forward Kebba Njie posted a double-double in his team’s 66-65 loss to NC State on Wednesday night. The 6’10” junior put up 10 points, 11 rebounds, an assist, and 2 blocks in 34 minutes. Njie shot 5 of 8 from the field in the defeat.

Notre Dame guard Markus Burton also played well in his team’s game on Wednesday. The sophomore from Mishawaka, IN recorded 15 points, 4 assists, and 2 made three-pointers in 33 minutes of playing time. Burton is leading the team in scoring with 18.4 points per game this year.

Duke Blue Devils Game Notes

Blue Devils guard Cooper Flagg notched a double-double in his team’s 76-47 blowout win over Pittsburgh on Tuesday night. The future NBA first-round pick logged 19 points, 10 rebounds, 5 assists, a steal, and 2 blocks. Flagg shot 7 of 11 from the floor and 1 of 2 from long distance in the victory.

Duke guard Tyrese Proctor stuffed the stat sheet in his team’s game on Tuesday. The junior from Sydney, Australia registered 13 points, 4 rebounds, 4 assists, and 3 made three-pointers in 33 minutes of game action. Proctor is third on the team in scoring with 11.7 points per game this season.

Notre Dame is 3-7 ATS in their last 10 games against Duke.

The Fighting Irish are 6-7 ATS when playing with the rest disadvantage since the start of last season.

Duke is 8-6 ATS when playing with the rest advantage since the start of last season.

Duke is 6-2 ATS in their last 8 games overall.

Notre Dame vs. Duke CBB Prediction:

Duke has been steamrolling teams of late. The Blue Devils have 7 straight wins by 11 points or more. They’ve won their last 3 games by an average of 26.3 points per game. All 3 of those games were against ACC foes, so the Blue Devils haven’t been simply feasting on cupcakes.

Duke’s defense has been stifling. The Blue Devils are third in the nation in defensive efficiency this year. They are only allowing 58.4 points per game this season, which ranks third in the country through 2+ months of the season. Notre Dame is 76th in the nation in offensive efficiency in 2024. I’m not sure how the Fighting Irish are going to score enough to keep this game close until the end. For that reason, among others, I’m laying the points with the Blue Devils at home this weekend.

Notre Dame vs. Duke CBB Prediction: DUKE BLUE DEVILS -19.5  

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