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Xavier vs. Illinois Prediction: Will Musketeers pull off another upset?

Illinois vs. Kentucky Illinois vs. Kentucky

​The Illinois Fighting Illini (21-12) are set to face the Xavier Musketeers (22-11) in the first round of the NCAA Tournament on Friday, March 21, 2025, at Fiserv Forum in Milwaukee, Wisconsin. Tip-off is scheduled for 9:45 p.m. EDT, with television coverage on CBS. What’s the best bet in tonight’s Xavier vs. Illinois matchup?

Game Matchup & Betting Odds

Xavier Musketeers (+3) vs. Illinois Fighting Illini (-3); o/u 161

9:45 p.m. ET, Friday, March 21, 2025

Fiserv Forum, Milwaukee, WI

TV: CBS

Xavier vs. Illinois Public Betting: Bettors Taking Dog

Our CBB Public Betting Information page indicates that 57% of public bettors are currently backing Xavier when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.

Team Overviews

Illinois enters the tournament as a No. 6 seed. The Fighting Illini have experienced a season marked by inconsistency, with notable victories offset by unexpected losses. Their offensive strategy emphasizes strong chemistry and ball movement, leading to a high-octane offense. ​

Xavier, the No. 11 seed, secured their tournament spot after a comeback victory over Texas in the First Four. The Musketeers are recognized for their proficient three-point shooting and robust defensive rebounding. Head coach Sean Miller brings a wealth of tournament experience, including eight appearances in the Sweet 16.

Key Matchup Factors

Three-Point Shooting vs. Perimeter Defense: Xavier’s strength lies in their three-point shooting, which could exploit Illinois’ inconsistent perimeter defense. ​

Rebounding Battle: Illinois excels in rebounding, a factor that could limit Xavier’s second-chance opportunities. ​

Coaching Experience: Sean Miller’s extensive tournament experience with Xavier could provide a strategic advantage over Illinois.

Betting Odds

According to oddsmakers from online sportsbook Bovada.lv, Illinois is favored by 3.5 points, with the over/under set at 160.5 points. Predictions vary, with some experts favoring Xavier for a potential upset, citing Illinois’ recent struggles. Others anticipate a high-scoring affair, with Illinois narrowly edging out Xavier.

Xavier vs. Illinois CBB Prediction:

Considering Illinois’ rebounding advantage and Xavier’s three-point shooting prowess, this matchup is expected to be closely contested. However, Illinois’ inconsistency and Xavier’s momentum from their recent victory could tilt the balance. I could see an outright upset tonight, but either way, I’m taking the Musketeers with the points.

Xavier vs. Illinois Hoops Prediction: XAVIER MUSKETEERS +3

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