Number 8 USC will travel to Boulder to face the Colorado Buffaloes at 12:00 PM ET this Saturday on ESPN. Can the Trojans come into Deion’s house and cover the massive 21-point spread as road favorites this weekend? Check out odds, trends and our USC vs. Colorado betting prediction ahead!
Game Matchup & Betting Odds
167 USC Trojans (-22) at Colorado Buffaloes (+22); o/u 73
12:00 PM ET, Saturday, September 30, 2023
Folsom Field
USC vs. Colorado Public Betting Information
As of this writing, the public is split but favoring the Tigers in this game. Our CFB Public Betting page shows that 54% of public bets are on LSU -17. Note that these numbers are subject to change and could be different once game time rolls around.
USC Trojans Game Notes
USC moved to 4-0 after defeating Arizona State in Tempe, 42-28. The Trojans avoided disaster after surprisingly trailing the Sun Devils throughout the contest, and they’ll look to avoid letting the Buffs stick around this weekend. USC is scoring 55.0 ppg, while passing for 377.3 yards per game, and rushing for 192.0 ypg. The Trojan defense allows 20.0 points per game.
Caleb Williams came through with another Heisman-worthy performance last weekend in the desert, passing for a season-high 322 yards, with three passing touchdowns, and two more scores on the ground.
The junior quarterback has been flawless through four starts, and if his defense can start to hold up, the Trojans have a real chance to run the table if they can pass this test in Boulder. Williams has thrown for 1,200 yards, with fifteen touchdowns to zero interceptions on the season.
Colorado Buffaloes Game Notes
Colorado moved to 3-1 after losing to Oregon in Eugene, 42-6. The Buffaloes were unable to keep their momentum going at the Zoo, and they’ll attempt to regroup here at home. Colorado is scoring 32.5 ppg, while passing for 353.3 yards per game, and rushing for 55.8 ypg. The Buffalo defense allows 33.2 points per game.
Shedeur Sanders struggled last weekend against Oregon, passing for a season-low 159 yards, with a touchdown toss. The junior quarterback has been much sharper than that through the course of the season, as he was also sacked seven times due to poor protection up front, and he’ll attempt to remind the nation why he’s a Heisman candidate this weekend against the men of Troy. Sanders has passed for 1,410 yards, with 11 touchdowns to one interception.
USC vs. Colorado Betting Trends
Southern California is 5-0 SU in its last 5 games when playing on the road against Colorado
Southern California is 5-0 SU in its last 5 games when playing Colorado
The total has gone OVER in 11 of Colorado’s last 15 games
Colorado is 2-6 ATS in its last 8 games
USC vs. Colorado Betting Prediction
Colorado will be handed another large sum of points, and I feel like we’re going to see a lot more fight from this team here at home. We should be in for a much more of a contested battle than the Week 4 contest in Eugene, and both schools may rev things up on the defensive end, after struggling to get stops last week. Spot Colorado the points for this PAC-12 matchup.
USC vs. Colorado Betting Prediction: OVER 73