49ers vs. Panthers Prediction & Odds
The 49ers are 6.5-point road favorites in Carolina on Sunday where they’ll take on the 1-3 Panthers at 4:05 p.m. ET.
With as bad as Baker Mayfield has performed to date, will the Niners cover the number and improve to 3-2 on the year?
Game Matchup & Betting Odds
471 San Francisco 49ers (-6.5) at 472 Carolina Panthers (+6.5); o/u 39.5
4:05 p.m. ET, Sunday, October 9, 2022
Bank of America Stadium, Charlotte, NC
49ers vs. Panthers Public Betting Information
Our NFL Public Betting Information page indicates that 77% of public bettors are currently backing the 49ers when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
San Francisco 49ers DFS Spin
Jimmy Garoppolo completed 16-of-27 passes for 239 yards and one touchdown in the 49ers’ 24-9, Week 4 win over the Rams. Unlike his counterpart on the other side, Garoppolo took care of the football and wasn’t sacked a single time despite the Niners missing star LT Trent Williams due to an ankle injury. Garoppolo got the ball out quick, and Deebo Samuel did all the work on his touchdown, turning a quick slant into a 57-yard score. Garoppolo had four pass plays of 20-plus yards. Not a volume passer, Garoppolo will be a low-end QB2 for Week 5 against the lowly Panthers in a spot the Niners should be able to run the ball.
Carolina Panthers DFS Spin
ESPN’s Dan Graziano reports “there’s a lot of buzz” the Panthers will fire head coach Matt Rhule “if things don’t pick up soon.” The Panthers have a 1-3 start under Rhule, who is facing three straight losing seasons, and are 11-26 since hiring Rhule in 2020. Another loss to the 49ers in Week 5 could add fuel to Rhule’s already hot seat. Firing Rhule in-season would give Carolina an early start at finding his replacement amid rumors the team plans to make a run at Sean Payton in 2023. Ex-Cardinals coach Steve Wilks would likely serve as the interim coach if Rhule is fired. The Panthers have been the league’s worst offense through the first four weeks, ranking last in the NFL in third-down percentage (26%) and total yards per game (263).
49ers vs. Panthers Betting Trends
49ers are 1-4 ATS in their last 5 meetings in Carolina
49ers are 2-6 ATS in their last 8 meetings
Favorite is 7-3 ATS in their last 10 meetings
49ers vs. Panthers Prediction:
I’m not in love with either side so I’m playing the total. The under is 6-0 in the 49ers’ last six conference games, is 5-0 in their last five road games and is 13-3 in their last 16 games overall. On the other side, the under is 5-2 in the Panthers’ last seven games, is 4-1 in their last five games played in the month of October and is 9-3 in their last 12 games after accumulating less than 90 yards rushing in their previous game.
NFL WEEK 5 PREDICTION: 49ERS/PANTHERS UNDER 39.5