The Cardinals have been ATS machines the first three weeks of the NFL season. That said, will they meet their match on Sunday when they visit the unbeaten 49ers? Check out odds, trends and our Cardinals vs. 49ers prediction.
Game Matchup & Betting Odds
275 Arizona Cardinals (+14) at 276 San Francisco 49ers (-14); o/u 43.5
4:25 p.m. ET, Sunday, October 1, 2023
Levi’s Stadium, Santa Clara, CA
TV: FOX
Cardinals vs. 49ers Public Betting Information
Our NFL Public Betting Information page indicates that 54% of public bettors are currently backing the 49ers when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
Arizona Cardinals DFS Spin
Cardinals RB James Conner is no longer listed on the team’s injury report ahead of Week 4’s matchup against the 49ers. Conner was limited in practice throughout the week but is ready to go for Week 4 against the 49ers. Serving as the Cardinals’ bell cow back through the first three weeks of the season, Conner should have another busy week against a stout 49ers defense as the Cardinals look to push their record to 2-2. Conner will be a volume-based RB2 play in a tough matchup
San Francisco 49ers DFS Spin
Deebo Samuel (ribs/knee) is questionable for Week 4 against the Cardinals. Deebo was not seen at the start of practice on Friday but was ultimately listed as a limited participant. He likely got in a very light session. Kyle Shanahan downplayed the severity of the issue earlier in the week, so Samuel should be able to suit up. Samuel and the 49ers get a great matchup with the Cardinals this week, putting the dynamic receiver in a position to drop another WR1 performance in Week 4.
Cardinals vs. 49ers Betting Trends
Arizona is 5-1 ATS in its last 6 games
The total has gone OVER in 4 of Arizona’s last 5 games when playing on the road against San Francisco
The 49ers are 5-0 ATS in their last 5 games at home
San Francisco is 5-0 SU in its last 5 games at home
Cardinals vs. 49ers Prediction:
Take the under. While I do expect the Cardinals to suffer their first ATS loss of the season sooner rather than later, I see more value in the under today at Levi’s Stadium. Arizona did a remarkable job in its first three games moving the ball offensively, but San Francisco is a different animal. I could see the Cardinals being held to 10 or fewer points in this contest. While the Niners could hang 40 on the board themselves, I see this more as a 27-10 game. Heck, even 31-10 keeps us under today’s total. Either way, I don’t see how Arizona moves the ball and San Francisco is coming off some bigger wins. Look for the 49ers to stay more in neutral today.
Cardinals vs. 49ers NFL Prediction: UNDER 43.5
