Chiefs vs. 49ers Prediction & Odds
Following their blockbuster trade with the Panthers for Christian McCaffrey, will the 49ers pull off the small upset on Sunday afternoon when they host the Chiefs at 4:25 p.m. ET?
Game Matchup & Betting Odds
469 Kansas City Chiefs (-1.5) at 470 San Francisco 49ers (+1.5); o/u 48.5
4:25 p.m. ET, Sunday, October 22, 2022
Levi’s Stadium, Santa Clara, CA
Chiefs vs. 49ers Public Betting Information
Our NFL Public Betting Information page indicates that 73% of public bettors are currently backing the Chiefs when it comes to the spread. This information is subject to change throughout the day, however, so be sure to check the link so you’re receiving the most up-to-date public betting data.
Kansas City Chiefs DFS Spin
Patrick Mahomes completed 25-of-40 pass attempts for 338 yards, two touchdowns, and two interceptions in the Chiefs’ 24-20 Week 6 loss to the Bills. Mahomes had a mostly uneven performance against a Buffalo defense that refused to blitz and still provided consistent pressure, sacking Mahomes three times. He connected with JuJu Smith-Schuster and Mecole Hardman for touchdowns, and JuJu was the team’s primary target while the Bills made every effort to slow down Travis Kelce. It’s a tough, possibly season-altering home loss for the Chiefs, though Mahomes remains the game’s most inventive, unflappable quarterback. He’ll remain an elite fantasy option in Week 7 against 49ers.
San Francisco 49ers DFS Spin
NFL insider Jordan Schultz reports there’s “a pretty good chance” Christian McCaffrey will play in Week 7 against the Chiefs. Schultz said McCaffrey, who was traded to the Niners on Thursday night, would not see a full complement of snaps but would be used around the end zone. 49ers head coach Kyle Shanahan said Friday that he had considered drawing up some red zone plays for his newly-acquired RB1. CMC drafters will probably have to start him against Kansas City if he suits up for lack of better options on their bench or the waiver wire. Jeff Wilson could retain some fantasy appeal if McCaffrey is going to be used this week on a (very) limited basis.
Chiefs vs. 49ers Betting Trends
Favorite is 4-1 ATS in their last 5 meetings
Chiefs are 5-1 ATS in their last 6 meetings
Home team is 5-0 ATS in their last 5 meetings
Chiefs vs. 49ers Prediction:
The Chiefs are just 1-4 against the spread in their last five games overall and have dropped five straight at the betting window in their last five games after allowing more than 250 yards passing in their previous game. On the other side, the Niners have covered six straight games at home, six straight games when facing an opponent with a winning record and are 6-1 against the number in their last seven games coming off a loss.
NFL WEEK 7 PREDICTION: SAN FRANCISCO 49ERS +1.5